Chk-ing in and Chk-ing out: kinase compartmentalization comes to checkpoint control.
نویسندگان
چکیده
Checkpoints are the sentinels of cell-cycle progression. In this issue of Molecular Cell, Yaffe and colleagues (Reinhardt et al., 2010) show that spatial and temporal resolution of Chk1 and MK2, checkpoint kinases with identical substrate specificity, are necessary to signal different aspects of DNA damage signaling.
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ورودعنوان ژورنال:
- Molecular cell
دوره 40 1 شماره
صفحات -
تاریخ انتشار 2010